BMS-695735 | DNC008930 | CHEMBL459729 | BMS695735 | BMS 695735 | BDBM27888 | CAS 1054315-48-8 | AnyMole

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HIT212715176

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HIT212715176

HIT ID:HIT212715176
Cas No:1054315-48-8
常用名:BMS-695735
别名:DNC008930, CHEMBL459729, BMS695735, BMS 695735, BDBM27888
别名:DNC008930, CHEMBL459729, BMS695735, BMS 695735, BDBM27888
IUPAC:4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-{5-[1-(3-fluoropropyl)piperidin-4-yl]-7-methyl-1H-1,3-benzodiazol-2-yl}-1,2-dihydropyridin-2-one
IUPAC:4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-{5-[1-(3-fluoropropyl)piperidin-4-yl]-7-methyl-1H-1,3-benzodiazol-2-yl}-1,2-dihydropyridin-2-one
InChI key:VWELCPLMPPEKOL-UHFFFAOYSA-N

分子式:C26H31ClFN7O
分子量:512.03
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:2.2923217
SMILES:Cc1cc(cc2nc([nH]c12)-c1c(NCCn2cc(Cl)cn2)cc[nH]c1=O)C1CCN(CCCF)CC1
SMILES:Cc1cc(cc2nc([nH]c12)-c1c(NCCn2cc(Cl)cn2)cc[nH]c1=O)C1CCN(CCCF)CC1

BMS-695735, a benzimidazole inhibitor of insulin-like growth factor-1 receptor, has broad-spectrum antitumor activity in vivo. It was found that BMS-695735 had strong inhibition of CYP3A4, induction of CYP3A4 mediated by PXR transactivation, poor water solubility, and high plasma protein binding.

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TargetMolSC
规格
货期
8-10周
纯度
-
¥ 13,900.00
1

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