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HIT212715398
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HIT212715398
  • HIT ID:HIT212715398
  • Cas No:944744-57-4
  • 常用名:CG0009
  • 别名:CG-0009, CG 0009
  • IUPAC:2-(4-{[2-(diethylamino)ethyl](methyl)amino}phenyl)-N-(4-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine-7-carboxamide
    IUPAC:2-(4-{[2-(diethylamino)ethyl](methyl)amino}phenyl)-N-(4-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine-7-carboxamide
  • InChI key:PFCCDXDYVNKMHB-UHFFFAOYSA-N
  • 分子式:C26H31N7O
  • 分子量:457.582
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):6
  • LogP:3.443217
  • SMILES:CCN(CC)CCN(C)c1ccc(cc1)-c1nc2c(ccnc2[nH]1)C(=O)Nc1cnccc1C
    SMILES:CCN(CC)CCN(C)c1ccc(cc1)-c1nc2c(ccnc2[nH]1)C(=O)Nc1cnccc1C
  • CG0009 is a potent and highly selective glycogen synthase kinase 3 (GSK3) inhibitor that inhibitions proliferation, induces apoptosis, and activates the p53-Bax pathway in breast cancer cells through cyclin D1 depletion. CG0009 inhibit breast cancer cell growth through cyclin D1 depletion and p53 activation, and thus may provide an innovative treatment approach for breast cancer resistant to hormone-based therapies.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 11,700.00
    1

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