Name: DB-766
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212715585
Cas No:423165-22-4
常用名:DB-766
别名:DB766
IUPAC:N-[3-(propan-2-yloxy)-4-{5-[2-(propan-2-yloxy)-4-(pyridine-2-imidamido)phenyl]furan-2-yl}phenyl]pyridine-2-carboximidamide
IUPAC:N-[3-(propan-2-yloxy)-4-{5-[2-(propan-2-yloxy)-4-(pyridine-2-imidamido)phenyl]furan-2-yl}phenyl]pyridine-2-carboximidamide
InChI key:QCFKWNGTLZQXRE-UHFFFAOYSA-N

分子式:C34H34N6O3
分子量:574.685
氢键供体数 (HBD):4
氢键受体数 (HBA):8
LogP:6.024816
SMILES:CC(C)Oc1cc(NC(=N)c2ccccn2)ccc1-c1ccc(o1)-c1ccc(NC(=N)c2ccccn2)cc1OC(C)C
SMILES:CC(C)Oc1cc(NC(=N)c2ccccn2)ccc1-c1ccc(o1)-c1ccc(NC(=N)c2ccccn2)cc1OC(C)C

DB-766 is a potential chemotherapeutic candidate for Chagas' disease treatment. DB-766 exhibits strong trypanocidal activity and excellent selectivity for bloodstream trypomastigotes and intracellular amastigotes (Y strain), giving IC(50)s of 60 and 25 nM, respectively. The trypanocidal efficacy of DB766, suggesting that this AIA may represent a new lead compound candidate to Chagas.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~