Name: Freselestat
Rating: 5 (10 reviews)

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HIT ID:HIT212716173
Cas No:208848-19-5
常用名:Freselestat
别名:ONO-PO 736, ONO-6818, ONO6818, ONO 6818
IUPAC:2-(5-amino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide
IUPAC:2-(5-amino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide
InChI key:YSIHYROEMJSOAS-UHFFFAOYSA-N

分子式:C23H28N6O4
分子量:452.515
氢键供体数 (HBD):2
氢键受体数 (HBA):7
LogP:1.5495456
SMILES:CC(C)C(NC(=O)Cn1c(ncc(N)c1=O)-c1ccccc1)C(=O)c1nnc(o1)C(C)(C)C
SMILES:CC(C)C(NC(=O)Cn1c(ncc(N)c1=O)-c1ccccc1)C(=O)c1nnc(o1)C(C)(C)C

Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9. Freselestat reduces inflammatory mediators during simulated cardiopulmonary bypass.

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