Name: IWP-051
Rating: 5 (10 reviews)

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HIT ID:HIT212716496
Cas No:1354041-91-0
常用名:IWP-051
别名:IWP051
IUPAC:5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}-3,4-dihydropyrimidin-4-one
IUPAC:5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}-3,4-dihydropyrimidin-4-one
InChI key:LIVYVCAUBHXIMI-UHFFFAOYSA-N

分子式:C17H11F2N5O2
分子量:355.305
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:2.543041
SMILES:Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(=O)[nH]1
SMILES:Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(=O)[nH]1

IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.

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