Name: MK-0952
Rating: 5 (10 reviews)

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HIT ID:HIT212717225
Cas No:934995-87-6
常用名:MK-0952
别名:MK 0952
IUPAC:(1R,2R)-2-{3'-[3-(cyclopropylcarbamoyl)-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl]-3-fluoro-[1,1'-biphenyl]-4-yl}cyclopropane-1-carboxylic acid
IUPAC:(1R,2R)-2-{3'-[3-(cyclopropylcarbamoyl)-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl]-3-fluoro-[1,1'-biphenyl]-4-yl}cyclopropane-1-carboxylic acid
InChI key:PSYPBAHXIIVDCJ-FCHUYYIVSA-N

分子式:C28H22FN3O4
分子量:483.499
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:3.868307
SMILES:OC(=O)[C@@H]1C[C@H]1c1ccc(cc1F)-c1cccc(c1)-n1cc(C(=O)NC2CC2)c(=O)c2cccnc12
SMILES:OC(=O)[C@@H]1C[C@H]1c1ccc(cc1F)-c1cccc(c1)-n1cc(C(=O)NC2CC2)c(=O)c2cccnc12

MK-0952 is a selective PDE4 inhibitor used to treat long-term memory loss and mild cognitive impairment. It is an intrinsically potent inhibitor and has shown limited whole blood activity.

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