Name: MK-912
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT212717243
Cas No:119942-70-0
常用名:MK-912
别名:MK912, MK 912
IUPAC:(2S,2'S)-1,5-dimethyl-17'-oxa-7'-azaspiro[1,5-diazinane-2,4'-tetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadecane]-1'(10'),11',13',15'-tetraen-6-one hydrochloride
IUPAC:(2S,2'S)-1,5-dimethyl-17'-oxa-7'-azaspiro[1,5-diazinane-2,4'-tetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadecane]-1'(10'),11',13',15'-tetraen-6-one hydrochloride
InChI key:ALYCEQJIRFYVGE-VASSOYJASA-N

分子式:C20H26ClN3O2
分子量:375.9
氢键供体数 (HBD):0
氢键受体数 (HBA):2
LogP:1.2731333
SMILES:Cl.[H][C@@]12C[C@@]3(CCN(C)C(=O)N3C)CCN1CCc1c2oc2ccccc12
SMILES:Cl.[H][C@@]12C[C@@]3(CCN(C)C(=O)N3C)CCN1CCc1c2oc2ccccc12

MK-912 is a potent novel selective alpha2-adrenergic receptor antagonist with oral activity to study the effect of short-term selective alpha2-blockers on fasting glucose (FPG) and islet function in non-insulin-dependent patients with diabetes mellitus (NIDDM).

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