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  3. HIT212717256
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HIT212717256
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HIT212717256
  • HIT ID:HIT212717256
  • Cas No:108929-03-9
  • 常用名:ML 23
  • 别名:ML-23, ML23
  • IUPAC:N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3,5-dinitroaniline
    IUPAC:N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3,5-dinitroaniline
  • InChI key:RAYPSZFWTIPCRF-UHFFFAOYSA-N
  • 分子式:C17H16N4O5
  • 分子量:356.338
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):6
  • LogP:3.2802174
  • SMILES:COc1ccc2[nH]cc(CCNc3cc(cc(c3)[N+]([O-])=O)[N+]([O-])=O)c2c1
    SMILES:COc1ccc2[nH]cc(CCNc3cc(cc(c3)[N+]([O-])=O)[N+]([O-])=O)c2c1
  • ML 23 is a melatonin analogue in the treatment and management of Parkinson's disease. ML-23 is a potential clinical candidate for the treatment of PD, and the present study has been undertaken to determine the efficacy of ML-23 in the 1-methyl-4-phenyl, 1,2,3,6 tetrahydropyridine (MPTP) model in the common marmoset. On all parameters, ML-23 produced a significant remission from MPTP-induced Parkinsonism, and this effect did not abate when ML-23 treatment was withdrawn. Conversely, a recurrence of Parkinsonian signs was not observed when ML-23 treatment was withdrawn and substituted with oral vehicle.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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