Name: Nafazatrom
Rating: 5 (10 reviews)

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HIT ID:HIT212717365
Cas No:59040-30-1
常用名:Nafazatrom
别名:Nafazatromum
IUPAC:3-methyl-1-[2-(naphthalen-2-yloxy)ethyl]-4,5-dihydro-1H-pyrazol-5-one
IUPAC:3-methyl-1-[2-(naphthalen-2-yloxy)ethyl]-4,5-dihydro-1H-pyrazol-5-one
InChI key:ISBUYSPRIJRBKX-UHFFFAOYSA-N

分子式:C16H16N2O2
分子量:268.316
氢键供体数 (HBD):0
氢键受体数 (HBA):3
LogP:2.5022686
SMILES:CC1=NN(CCOc2ccc3ccccc3c2)C(=O)C1 |t:1|
SMILES:CC1=NN(CCOc2ccc3ccccc3c2)C(=O)C1 |t:1|

Nafazatrom is a pyrazolinone derivative and lipoxygenase inhibitor that increases endogenous prostacyclin (PGI2) and has experimental anticancer activity. Nafazatrom is also an antithrombotic drug that increases prostacyclin levels and reduces the incidence of arrhythmias associated with cardiac injury.

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