Name: Redaporfin
Rating: 5 (10 reviews)

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HIT ID:HIT212717928
Cas No:1224104-08-8
常用名:Redaporfin
别名:LUZ-11, LUZ11, LUZ 11, F-2BMet, F2BMet, F 2BMet
别名:LUZ-11, LUZ11, LUZ 11, F-2BMet, F2BMet, F 2BMet
IUPAC:2,4-difluoro-N-methyl-3-{7,12,17-tris[2,6-difluoro-3-(methylsulfamoyl)phenyl]-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1,3(24),6,8,10,12,16(22),17,19-nonaen-2-yl}benzene-1-sulfonamide
IUPAC:2,4-difluoro-N-methyl-3-{7,12,17-tris[2,6-difluoro-3-(methylsulfamoyl)phenyl]-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1,3(24),6,8,10,12,16(22),17,19-nonaen-2-yl}benzene-1-sulfonamide
InChI key:CKRVBMUJCFKRND-ZXWMLXKTSA-N

分子式:C48H38F8N8O8S4
分子量:1135.11
氢键供体数 (HBD):6
氢键受体数 (HBA):10
LogP:6.0964637
SMILES:CNS(=O)(=O)c1ccc(F)c(c1F)-c1c2CCc(n2)c(-c2c(F)ccc(c2F)S(=O)(=O)NC)c2ccc([nH]2)c(c2CCc(n2)c(-c2c(F)ccc(c2F)S(=O)(=O)NC)c2ccc1[nH]2)-c1c(F)ccc(c1F)S(=O)(=O)NC
SMILES:CNS(=O)(=O)c1ccc(F)c(c1F)-c1c2CCc(n2)c(-c2c(F)ccc(c2F)S(=O)(=O)NC)c2ccc([nH]2)c(c2CCc(n2)c(-c2c(F)ccc(c2F)S(=O)(=O)NC)c2ccc1[nH]2)-c1c(F)ccc(c1F)S(=O)(=O)NC

Redaporfin, also known as F-2BMet or LUZ-11, is a photosensitizer for Photodynamic Therapy (PDT) of cancer. Redaporfin showed a high efficacy in the treatment of male BALB/c mice with subcutaneously implanted colon (CT26) tumours. Vascular-PDT with 1.5 mg/kg redaporfin and a light dose of 74 J/cm² led to the complete tumour regression in 83% of the mice.

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