Name: SRI-29132
Rating: 5 (10 reviews)

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HIT ID:HIT212718328
Cas No:1482305-44-1
常用名:SRI-29132
别名:TPZ-11, TPZ11, TPZ 11, SRI29132, SRI 29132
别名:TPZ-11, TPZ11, TPZ 11, SRI29132, SRI 29132
IUPAC:1-(piperidin-1-yl)-2-{[3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]sulfanyl}butan-1-one
IUPAC:1-(piperidin-1-yl)-2-{[3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]sulfanyl}butan-1-one
InChI key:IPCBRXKQIWRBBQ-UHFFFAOYSA-N

分子式:C18H21N5OS2
分子量:387.52
氢键供体数 (HBD):0
氢键受体数 (HBA):4
LogP:3.4658256
SMILES:CCC(Sc1ccc2nnc(-c3cccs3)n2n1)C(=O)N1CCCCC1
SMILES:CCC(Sc1ccc2nnc(-c3cccs3)n2n1)C(=O)N1CCCCC1

SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons.

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