Name: SST-02
Rating: 5 (10 reviews)

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HIT ID:HIT212718329
Cas No:
常用名:SST-02
别名:SST02, SST 02
IUPAC:3-{bis[(9Z,12Z)-octadeca-9,12-dien-1-yl]amino}propan-1-ol
IUPAC:3-{bis[(9Z,12Z)-octadeca-9,12-dien-1-yl]amino}propan-1-ol
InChI key:SGQSGJUTBKNKIB-MAZCIEHSSA-N

分子式:C39H73NO
分子量:572.019
氢键供体数 (HBD):1
氢键受体数 (HBA):2
LogP:13.208061
SMILES:CCCCC\C=C/C\C=C/CCCCCCCCN(CCCO)CCCCCCCC\C=C/C\C=C/CCCCC
SMILES:CCCCC\C=C/C\C=C/CCCCCCCCN(CCCO)CCCCCCCC\C=C/C\C=C/CCCCC

SST-02 is a potent cationic lipid for siRNA-Lipid Nanoparticles. SST-02 possesses a simple chemical structure and is synthesized just in one step. SST-02 showed an ID50 of 0.02 mg/kg in the factor VII (FVII) model. Rats administered with 3 mg/kg of SST-02 LNP did not show changes in body weight, blood chemistry, or hematological parameters, while the AST level decreased at a dose of 5 mg/kg. The use of SST-02 avoids a lengthy synthetic route and may thus decrease the future cost of nucleic acid therapeutics.

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