Name: Tie2 Inhibitor 7
Rating: 5 (10 reviews)

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HIT ID:HIT212719264
Cas No:1020412-97-8
常用名:Tie2 Inhibitor 7
IUPAC:5-(4-{[({[(1S)-1-cyclohexylethyl]carbamoyl}methyl)[(4-methylphenoxy)carbonyl]amino]methyl}phenyl)pyridine-3-carboxylic acid
IUPAC:5-(4-{[({[(1S)-1-cyclohexylethyl]carbamoyl}methyl)[(4-methylphenoxy)carbonyl]amino]methyl}phenyl)pyridine-3-carboxylic acid
InChI key:GHHDFOFSMBLLDX-QFIPXVFZSA-N

分子式:C31H35N3O5
分子量:529.637
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:5.0499372
SMILES:C[C@H](NC(=O)CN(Cc1ccc(cc1)-c1cncc(c1)C(O)=O)C(=O)Oc1ccc(C)cc1)C1CCCCC1
SMILES:C[C@H](NC(=O)CN(Cc1ccc(cc1)-c1cncc(c1)C(O)=O)C(=O)Oc1ccc(C)cc1)C1CCCCC1

Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.

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