Name: PKSI-527
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212720220
Cas No:128837-71-8
常用名:PKSI-527
IUPAC:2-{4-[(2S)-3-phenyl-2-{[(1r,4r)-4-(aminomethyl)cyclohexyl]formamido}propanamido]phenyl}acetic acid hydrochloride
IUPAC:2-{4-[(2S)-3-phenyl-2-{[(1r,4r)-4-(aminomethyl)cyclohexyl]formamido}propanamido]phenyl}acetic acid hydrochloride
InChI key:NAXNMKUKSBHHMP-JLBKCEDKSA-N

分子式:C25H32ClN3O4
分子量:474
氢键供体数 (HBD):4
氢键受体数 (HBA):5
LogP:0.64046985
SMILES:Cl.NC[C@H]1CC[C@@H](CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(CC(O)=O)cc1 |wU:6.8,12.11,wD:3.1,(12.56,,;-8.96,-3.78,;-8.96,-2.24,;-7.63,-1.47,;-6.29,-2.24,;-4.96,-1.47,;-4.96,.07,;-6.29,.84,;-7.63,.07,;-3.63,.84,;-3.63,2.38,;-2.29,.07,;-.96,.84,;-.96,2.38,;.38,3.15,;.38,4.69,;1.71,5.46,;3.04,4.69,;3.04,3.15,;1.71,2.38,;.38,.07,;.38,-1.47,;1.71,.84,;3.04,.07,;4.38,.84,;5.71,.07,;5.71,-1.47,;7.04,-2.24,;7.04,-3.78,;5.71,-4.55,;8.38,-4.55,;4.38,-2.24,;3.04,-1.47,)|
SMILES:Cl.NC[C@H]1CC[C@@H](CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(CC(O)=O)cc1 |wU:6.8,12.11,wD:3.1,(12.56,,;-8.96,-3.78,;-8.96,-2.24,;-7.63,-1.47,;-6.29,-2.24,;-4.96,-1.47,;-4.96,.07,;-6.29,.84,;-7.63,.07,;-3.63,.84,;-3.63,2.38,;-2.29,.07,;-.96,.84,;-.96,2.38,;.38,3.15,;.38,4.69,;1.71,5.46,;3.04,4.69,;3.04,3.15,;1.71,2.38,;.38,.07,;.38,-1.47,;1.71,.84,;3.04,.07,;4.38,.84,;5.71,.07,;5.71,-1.47,;7.04,-2.24,;7.04,-3.78,;5.71,-4.55,;8.38,-4.55,;4.38,-2.24,;3.04,-1.47,)|

PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times.

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~