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HIT212722689
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HIT212722689
  • HIT ID:HIT212722689
  • Cas No:19117-92-1
  • 常用名:2-chloro Palmitic Acid
  • IUPAC:2-chlorohexadecanoic acid
    IUPAC:2-chlorohexadecanoic acid
  • InChI key:LDQUHRSWFMWRNG-UHFFFAOYSA-N
  • 分子式:C16H31ClO2
  • 分子量:290.87
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):2
  • LogP:6.7401085
  • SMILES:CCCCCCCCCCCCCCC(Cl)C(O)=O
    SMILES:CCCCCCCCCCCCCCC(Cl)C(O)=O
  • 2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,560.00
    1
  • 供应商
    AA BlocksBB
    规格
    货期
    4-6周
    纯度
    -
    待询
    1

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