Name: 8-iso-13,14-dihydro-15-keto Prostaglandin F2α
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HIT ID:HIT212722710
Cas No:191919-02-5
常用名:8-iso-13,14-dihydro-15-keto Prostaglandin F2α
常用名:8-iso-13,14-dihydro-15-keto Prostaglandin F2α
别名:8-iso-13,14-dihydro-15-keto Prostaglandin F2α
别名:8-iso-13,14-dihydro-15-keto Prostaglandin F2α
IUPAC:(5Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid
IUPAC:(5Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid
InChI key:VKTIONYPMSCHQI-JPRPWBOBSA-N

分子式:C20H34O5
分子量:354.487
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:3.0245695
SMILES:CCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@H]1C\C=C/CCCC(O)=O
SMILES:CCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@H]1C\C=C/CCCC(O)=O

8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits. Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF2α was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF2α weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.

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