Name: Moxonidine hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212726145
Cas No:75536-04-8
常用名:Moxonidine hydrochloride
别名:盐酸莫索尼定, BDF5895hydrochloride
IUPAC:4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine hydrochloride
IUPAC:4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine hydrochloride
InChI key:ZZPAWQYZQVUVHX-UHFFFAOYSA-N

分子式:C9H13Cl2N5O
分子量:278.14
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:1.5387771
SMILES:Cl.COc1nc(C)nc(Cl)c1NC1=NCCN1 |t:12|
SMILES:Cl.COc1nc(C)nc(Cl)c1NC1=NCCN1 |t:12|

Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.<br/><br/>Target: I1-R<br/><br/>Moxonidine Hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Moxonidine reduced stimulated NE overflow (log EC50: -6.15 +/- 0.14). AGN192403, a selective ligand at I1-R, had no influence on the dose-response curve of moxonidine (log EC50: -6.01 +/- 0.25). The hypotensive and bradycardic actions of moxonidine but not clonidine are mediated through imidazoline receptors and are dependent on intact noradrenergic pathways within the RVLM. Furthermore, the noradrenergic innervation may be associated with a 42 kDa imidazoline receptor protein.

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