Name: I-SAP
Rating: 5 (10 reviews)

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HIT ID:HIT212728849
Cas No:133538-58-6
常用名:I-SAP
IUPAC:(5Z)-7-[(1S,2S,3S,5R)-3-(4-iodobenzenesulfonamido)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl]hept-5-enoic acid
IUPAC:(5Z)-7-[(1S,2S,3S,5R)-3-(4-iodobenzenesulfonamido)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl]hept-5-enoic acid
InChI key:SZNMERGTFJHNSM-JAWYFFTGSA-N

分子式:C22H30INO4S
分子量:531.45
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:5.1341987
SMILES:CC1(C)[C@@H]2C[C@H]1[C@H](C\C=C/CCCC(O)=O)[C@H](C2)NS(=O)(=O)c1ccc(I)cc1
SMILES:CC1(C)[C@@H]2C[C@H]1[C@H](C\C=C/CCCC(O)=O)[C@H](C2)NS(=O)(=O)c1ccc(I)cc1

I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.

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