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- HIT ID:HIT212728860
- Cas No:1354630-46-8
- 常用名:DYn-2
- InChI key:UNMICBPHYXLMRA-UHFFFAOYSA-N
- 分子式:C11H14O2
- 分子量:178.231
- 氢键供体数 (HBD):0
- 氢键受体数 (HBA):2
- LogP:2.335017
- Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH). Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells. DYn-2 consists of 1,3-cyclohexanedione coupled to an alkyne moiety by a 3-carbon spacer. The cyclohexanedione group selectively reacts with protein sulfenic acid modifications. The alkyne group of DYn-2 can then be detected using azide-bearing tags by standard click chemistry. This approach offers superior sensitivity relative to using azide-modified probes with alkynyl detection tags.
市场产品/服务共显示3个结果
- 供应商TargetMol规格货期35日内发货纯度-¥ 1,370.001
- 供应商Enamine规格货期4-6周纯度-¥ 3,023.001
- 供应商AA Blocks规格货期4-6周纯度-待询1
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