Name: BTC AM
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

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HIT ID:HIT212729385
Cas No:176767-94-5
常用名:BTC AM
IUPAC:(acetyloxy)methyl 2-({2-[(acetyloxy)methoxy]-2-oxoethyl}[2-(2-{[3-(1,3-benzothiazol-2-yl)-7-[bis({2-[(acetyloxy)methoxy]-2-oxoethyl})amino]-2-oxo-2H-chromen-6-yl]oxy}ethoxy)-4-methylphenyl]amino)acetate
IUPAC:(acetyloxy)methyl 2-({2-[(acetyloxy)methoxy]-2-oxoethyl}[2-(2-{[3-(1,3-benzothiazol-2-yl)-7-[bis({2-[(acetyloxy)methoxy]-2-oxoethyl})amino]-2-oxo-2H-chromen-6-yl]oxy}ethoxy)-4-methylphenyl]amino)acetate
InChI key:JHWYIECNPLLVMW-UHFFFAOYSA-N

分子式:C45H45N3O20S
分子量:979.92
氢键供体数 (HBD):0
氢键受体数 (HBA):14
LogP:4.1251125
SMILES:CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccc(C)cc1OCCOc1cc2cc(-c3nc4ccccc4s3)c(=O)oc2cc1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O
SMILES:CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccc(C)cc1OCCOc1cc2cc(-c3nc4ccccc4s3)c(=O)oc2cc1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O

BTC AM is a cell-permeable acetoxy-methyl ester of BTC . As BTC AM enters cells, it is hydrolyzed by intracellular esterases to produce BTC. BTC is a low affinity calcium indicator (Kd = 7-26 μM) that displays excitation/emission spectra of 401/529 nm, respectively. It exhibits a shift in the excitation maximum from approximately 480 to 401 nm upon calcium binding, enabling determination of ratiometric calcium measurements. BTC is suitable for detecting elevated calcium levels associated with activation of smooth muscle, neurons, and intracellular calcium stores.

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