Name: 15(R)-17-phenyl trinor Prostaglandin F2α
Rating: 5 (10 reviews)

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HIT ID:HIT212730466
Cas No:41639-71-8
常用名:15(R)-17-phenyl trinor Prostaglandin F2α
常用名:15(R)-17-phenyl trinor Prostaglandin F2α
别名:15(R)-17-phenyl trinor Prostaglandin F2α
别名:15(R)-17-phenyl trinor Prostaglandin F2α
IUPAC:(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]hept-5-enoic acid
IUPAC:(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]hept-5-enoic acid
InChI key:YFHHIZGZVLHBQZ-MTDOSWCTSA-N

分子式:C23H32O5
分子量:388.504
氢键供体数 (HBD):4
氢键受体数 (HBA):5
LogP:2.855721
SMILES:O[C@H](CCc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
SMILES:O[C@H](CCc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O

17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or unnatural" isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity

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