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  3. HIT212730793
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HIT212730793
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HIT212730793
  • HIT ID:HIT212730793
  • Cas No:368451-07-4
  • 常用名:6-hydroxy Bexarotene
  • IUPAC:4-[1-(6-hydroxy-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
    IUPAC:4-[1-(6-hydroxy-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
  • InChI key:WTWGVKDCAJSUBZ-UHFFFAOYSA-N
  • 分子式:C24H28O3
  • 分子量:364.485
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):3
  • LogP:5.7097263
  • SMILES:Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CC(O)C2(C)C
    SMILES:Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CC(O)C2(C)C
  • 6-Hydroxy Bexarotene, an oxidative metabolite of bexarotene, serves as a high-affinity ligand for retinoid X receptors (RXRs), specifically binding to RXRα, RXRβ, and RXRγ, as well as to the retinoic acid receptor α (RARα) with dissociation constants (Kds) of 3.46, 4.21, 4.83, and 8.17 μM, respectively. It demonstrates selective activation of RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro, with half-maximal effective concentrations (EC50s) of 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively.
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
    纯度
    -
    ¥ 987.00
    1
  • 供应商
    AA BlocksBB
    规格
    货期
    4-6周
    纯度
    -
    待询
    1

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