Name: Org 24598
Rating: 5 (10 reviews)

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HIT ID:HIT212730873
Cas No:372198-97-5
常用名:Org 24598
IUPAC:2-{methyl[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amino}acetic acid
IUPAC:2-{methyl[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amino}acetic acid
InChI key:KZWQAWBTWNPFPW-QGZVFWFLSA-N

分子式:C19H20F3NO3
分子量:367.368
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:1.3037537
SMILES:CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC(O)=O
SMILES:CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC(O)=O

Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo.

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