Name: C8 Galactosylceramide (d18:1/8:0)
Rating: 5 (10 reviews)

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HIT ID:HIT212730877
Cas No:41613-16-5
常用名:C8 Galactosylceramide (d18:1/8:0)
常用名:C8 Galactosylceramide (d18:1/8:0)
别名:C8 Galactosylceramide (d18:1/8:0)
IUPAC:N-[(2S,3R,4E)-3-hydroxy-1-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadec-4-en-2-yl]octanamide
IUPAC:N-[(2S,3R,4E)-3-hydroxy-1-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadec-4-en-2-yl]octanamide
InChI key:LCEXEEHGNKGJES-SWMJIITPSA-N

分子式:C32H61NO8
分子量:587.839
氢键供体数 (HBD):6
氢键受体数 (HBA):8
LogP:5.53797
SMILES:CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCC
SMILES:CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NC(=O)CCCCCCC

C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo. It also activates NF-κB production in C6 glioma cells when used at a concentration of 10 μM.

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