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  3. HIT212731232
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HIT212731232
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HIT212731232
  • HIT ID:HIT212731232
  • Cas No:443919-96-8
  • 常用名:CAY10416
  • IUPAC:3-{[3-fluoro-5-(4-methoxyoxan-4-yl)phenoxy]methyl}-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole
    IUPAC:3-{[3-fluoro-5-(4-methoxyoxan-4-yl)phenoxy]methyl}-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole
  • InChI key:WSCRVCJAJAXULJ-UHFFFAOYSA-N
  • 分子式:C29H29FN2O5S
  • 分子量:536.62
  • 氢键供体数 (HBD):0
  • 氢键受体数 (HBA):6
  • LogP:4.0183067
  • SMILES:COC1(CCOCC1)c1cc(F)cc(OCc2cc(-c3ccccc3)n(n2)-c2ccc(cc2)S(C)(=O)=O)c1
    SMILES:COC1(CCOCC1)c1cc(F)cc(OCc2cc(-c3ccccc3)n(n2)-c2ccc(cc2)S(C)(=O)=O)c1
  • Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 μM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC50 value of 83 μM.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
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    货期
    35日内发货
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    ¥ 1,430.00
    1
  • 供应商
    AA BlocksBB
    规格
    货期
    4-6周
    纯度
    -
    待询
    1

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