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HIT212731345
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HIT212731345
  • HIT ID:HIT212731345
  • Cas No:53467-23-5
  • 常用名:(3S)-hydroxy Quinidine
  • IUPAC:(3S,4S,6R)-3-ethenyl-6-[(S)-hydroxy(6-methoxyquinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-3-ol
    IUPAC:(3S,4S,6R)-3-ethenyl-6-[(S)-hydroxy(6-methoxyquinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-3-ol
  • InChI key:BSRUJCFCZKMFMB-LGWHJFRWSA-N
  • 分子式:C20H24N2O3
  • 分子量:340.423
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):5
  • LogP:1.6659791
  • SMILES:COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@]4(O)C=C)c2c1 |TLB:10:12:19.18:16.15|
    SMILES:COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@]4(O)C=C)c2c1 |TLB:10:12:19.18:16.15|
  • (3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.
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    TargetMolSC
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  • 供应商
    AA BlocksBB
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    4-6周
    纯度
    -
    待询
    1

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