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- HIT ID:HIT212731922
- Cas No:5707-55-1
- 常用名:DOPAL
- InChI key:IADQVXRMSNIUEL-UHFFFAOYSA-N
- 分子式:C8H8O3
- 分子量:152.149
- 氢键供体数 (HBD):2
- 氢键受体数 (HBA):3
- LogP:0.8452472
- DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.[4]
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