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  3. HIT212732029
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HIT212732029
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HIT212732029
  • HIT ID:HIT212732029
  • Cas No:60719-83-7
  • 常用名:Alaproclate (hydrochloride)
  • IUPAC:1-(4-chlorophenyl)-2-methylpropan-2-yl 2-aminopropanoate hydrochloride
    IUPAC:1-(4-chlorophenyl)-2-methylpropan-2-yl 2-aminopropanoate hydrochloride
  • InChI key:OPAKSOWFKIUFNP-UHFFFAOYSA-N
  • 分子式:C13H19Cl2NO2
  • 分子量:292.2
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):2
  • LogP:2.8815134
  • SMILES:Cl.CC(N)C(=O)OC(C)(C)Cc1ccc(Cl)cc1
    SMILES:Cl.CC(N)C(=O)OC(C)(C)Cc1ccc(Cl)cc1
  • Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentrations up to 100 μM.2 It increases sirtuin 1 (SIRT1) levels in N2a murine neuroblastoma cells expressing apolipoprotein E4 (ApoE4; IC50 = 2.3 μM) and in the hippocampus in the FXFAD-ApoE4 transgenic mouse model of Alzheimer's disease when administered at a dose of 20 mg/kg twice daily.3 Alaproclate (40 mg/kg) decreases immobility time in the forced swim test in rats, indicating antidepressant-like activity.4
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    TargetMolSC
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    ¥ 1,880.00
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  • 供应商
    AA BlocksBB
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    4-6周
    纯度
    -
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    1

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