Name: Resveratrol-3-O-sulfate sodium
Rating: 5 (10 reviews)

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HIT ID:HIT212732486
Cas No:858127-11-4
常用名:Resveratrol-3-O-sulfate sodium
IUPAC:sodium 3-hydroxy-5-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl sulfate
IUPAC:sodium 3-hydroxy-5-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl sulfate
InChI key:OWGXRCOCVOPKAM-TYYBGVCCSA-M

分子式:C14H11NaO6S
分子量:330.29
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:2.9270775
SMILES:[Na+].Oc1ccc(\C=C\c2cc(O)cc(OS([O-])(=O)=O)c2)cc1
SMILES:[Na+].Oc1ccc(\C=C\c2cc(O)cc(OS([O-])(=O)=O)c2)cc1

Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 μM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 μM, and induces apoptosis at concentrations of 25 and 50 μM. Resveratrol-3-O-sulfate also displaces rosiglitazone from the outer mitochondrial protein mitoNEET (IC50 = 3.36 μM for the human protein), indicating that it binds to the thiazolidine-2,4-dione (TZD) binding pocket.

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