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  3. HIT212732604
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HIT212732604
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HIT212732604
  • HIT ID:HIT212732604
  • Cas No:854127-90-5
  • 常用名:LY303511 hydrochloride
  • IUPAC:8-phenyl-2-(piperazin-1-yl)-4H-chromen-4-one dihydrochloride
    IUPAC:8-phenyl-2-(piperazin-1-yl)-4H-chromen-4-one dihydrochloride
  • InChI key:GUISTZFSXPSDQO-UHFFFAOYSA-N
  • 分子式:C19H20Cl2N2O2
  • 分子量:379.28
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):4
  • LogP:3.0952065
  • SMILES:Cl.Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
    SMILES:Cl.Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
  • LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.
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  • 供应商
    TargetMolSC
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    35日内发货
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    ¥ 780.00
    1
  • 供应商
    AA BlocksBB
    规格
    货期
    4-6周
    纯度
    -
    待询
    1

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