Name: N-methyl Paroxetine
Rating: 5 (10 reviews)

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HIT ID:HIT212734325
Cas No:110429-36-2
常用名:N-methyl Paroxetine
IUPAC:(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine
IUPAC:(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine
InChI key:MOJZPKOBKCXNKG-YJBOKZPZSA-N

分子式:C20H22FNO3
分子量:343.398
氢键供体数 (HBD):0
氢键受体数 (HBA):4
LogP:4.327
SMILES:CN1CC[C@H]([C@H](COc2ccc3OCOc3c2)C1)c1ccc(F)cc1
SMILES:CN1CC[C@H]([C@H](COc2ccc3OCOc3c2)C1)c1ccc(F)cc1

N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin uptake in rat brain synaptosomes with an IC50 value of 22 nM. N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.

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