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HIT212741260
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HIT212741260
  • HIT ID:HIT212741260
  • Cas No:1217619-62-9
  • 常用名:(R)-nitro-Blebbistatin
  • IUPAC:(3aR)-3a-hydroxy-7-nitro-1-phenyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one
    IUPAC:(3aR)-3a-hydroxy-7-nitro-1-phenyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one
  • InChI key:VIMYHNYWFMRDKQ-KRWDZBQOSA-N
  • 分子式:C17H13N3O4
  • 分子量:323.308
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):6
  • LogP:2.3060877
  • SMILES:O[C@]12CCN(C1=Nc1cc(ccc1C2=O)[N+]([O-])=O)c1ccccc1 |c:6|
    SMILES:O[C@]12CCN(C1=Nc1cc(ccc1C2=O)[N+]([O-])=O)c1ccccc1 |c:6|
  • (R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin , which is the inactive form of (-)-blebbistatin . Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereochemistry as the inactive (+)-blebbistatin enantiomer.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 2,870.00
    1
  • 供应商
    AA BlocksBB
    规格
    货期
    4-6周
    纯度
    -
    待询
    1

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