Name: Dapagliflozin-3-O-β-D-Glucuronide
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212741271
Cas No:1351438-75-9
常用名:Dapagliflozin-3-O-β-D-Glucuronide
常用名:Dapagliflozin-3-O-β-D-Glucuronide
IUPAC:(2S,3S,4S,5R,6R)-6-{[(2S,3S,4R,5R,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid
IUPAC:(2S,3S,4S,5R,6R)-6-{[(2S,3S,4R,5R,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid
InChI key:ZYZULHSUKTZGTR-PTNNFGGUSA-N

分子式:C27H33ClO12
分子量:585
氢键供体数 (HBD):7
氢键受体数 (HBA):12
LogP:0.6603392
SMILES:CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)[C@H]2O)cc1
SMILES:CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)[C@H]2O)cc1

Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2]

市场产品/服务共显示3个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~