Name: Diminutol
Rating: 5 (10 reviews)

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HIT ID:HIT212741332
Cas No:361431-33-6
常用名:Diminutol
IUPAC:(2R)-2-({6-[(3-aminophenyl)sulfanyl]-9-(propan-2-yl)-9H-purin-2-yl}amino)-3-methylbutan-1-ol
IUPAC:(2R)-2-({6-[(3-aminophenyl)sulfanyl]-9-(propan-2-yl)-9H-purin-2-yl}amino)-3-methylbutan-1-ol
InChI key:NLQYQPZBKDUXKS-HNNXBMFYSA-N

分子式:C19H26N6OS
分子量:386.52
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:3.4203281
SMILES:CC(C)[C@H](CO)Nc1nc(Sc2cccc(N)c2)c2ncn(C(C)C)c2n1
SMILES:CC(C)[C@H](CO)Nc1nc(Sc2cccc(N)c2)c2ncn(C(C)C)c2n1

Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.

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