Name: BPIQ-II (hydrochloride)
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212742442
Cas No:171179-37-6
常用名:BPIQ-II (hydrochloride)
IUPAC:N-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine hydrochloride
IUPAC:N-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine hydrochloride
InChI key:FENLVGDZGJBHPT-UHFFFAOYSA-N

分子式:C15H11BrClN5
分子量:376.64
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:3.5144567
SMILES:Cl.Brc1cccc(Nc2ncnc3cc4nc[nH]c4cc23)c1
SMILES:Cl.Brc1cccc(Nc2ncnc3cc4nc[nH]c4cc23)c1

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~