Name: Quinacrine analog 34
Rating: 5 (10 reviews)

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HIT ID:HIT212742459
Cas No:1411646-44-0
常用名:Quinacrine analog 34
IUPAC:6-chloro-N-[2-(4-methylpiperazin-1-yl)ethyl]-1,2,3,4-tetrahydroacridin-9-amine
IUPAC:6-chloro-N-[2-(4-methylpiperazin-1-yl)ethyl]-1,2,3,4-tetrahydroacridin-9-amine
InChI key:AKZZUONQDIGIBX-UHFFFAOYSA-N

分子式:C20H27ClN4
分子量:358.91
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:4.209
SMILES:CN1CCN(CCNc2c3CCCCc3nc3cc(Cl)ccc23)CC1
SMILES:CN1CCN(CCNc2c3CCCCc3nc3cc(Cl)ccc23)CC1

Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.

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