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  3. HIT212742460
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HIT212742460
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HIT212742460
  • HIT ID:HIT212742460
  • Cas No:1453835-43-2
  • 常用名:LLP-3
  • IUPAC:4-[3,5-bis(benzyloxy)phenyl]-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
    IUPAC:4-[3,5-bis(benzyloxy)phenyl]-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
  • InChI key:NZRBRJQYGLEINZ-UHFFFAOYSA-N
  • 分子式:C32H23ClN2O4
  • 分子量:535
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):5
  • LogP:6.0766068
  • SMILES:Oc1ccc(Cl)cc1-c1cc(-c2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)c(C#N)c(=O)[nH]1
    SMILES:Oc1ccc(Cl)cc1-c1cc(-c2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)c(C#N)c(=O)[nH]1
  • Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 μM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    1-3天
    纯度
    -
    ¥ 1,400.00
    1
  • 供应商
    AA BlocksBB
    规格
    货期
    4-6周
    纯度
    -
    待询
    1

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