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  3. HIT212742464
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HIT212742464
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HIT212742464
  • HIT ID:HIT212742464
  • Cas No:1841421-67-7
  • 常用名:CAY10703
  • IUPAC:N-(2-{bis[2-(2,2-dichloroacetamido)ethyl]amino}ethyl)-2,2-dichloroacetamide
    IUPAC:N-(2-{bis[2-(2,2-dichloroacetamido)ethyl]amino}ethyl)-2,2-dichloroacetamide
  • InChI key:CXWSCUTUXVKDSD-UHFFFAOYSA-N
  • 分子式:C12H18Cl6N4O3
  • 分子量:479
  • 氢键供体数 (HBD):3
  • 氢键受体数 (HBA):4
  • LogP:-0.023797141
  • SMILES:ClC(Cl)C(=O)NCCN(CCNC(=O)C(Cl)Cl)CCNC(=O)C(Cl)Cl
    SMILES:ClC(Cl)C(=O)NCCN(CCNC(=O)C(Cl)Cl)CCNC(=O)C(Cl)Cl
  • Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases. CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA. It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells. It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
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    -
    ¥ 812.00
    1
  • 供应商
    AA BlocksBB
    规格
    货期
    4-6周
    纯度
    -
    待询
    1

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