Name: CAY10719
Rating: 5 (10 reviews)

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HIT ID:HIT212742498
Cas No:1942919-63-2
常用名:CAY10719
别名:CAY10719
IUPAC:1-(3,4-dichlorophenyl)-2-(4-methoxybenzoyl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole
IUPAC:1-(3,4-dichlorophenyl)-2-(4-methoxybenzoyl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole
InChI key:AKQFVWUCZTWDKB-UHFFFAOYSA-N

分子式:C25H20Cl2N2O2
分子量:451.35
氢键供体数 (HBD):1
氢键受体数 (HBA):2
LogP:5.8890214
SMILES:COc1ccc(cc1)C(=O)N1CCc2c([nH]c3ccccc23)C1c1ccc(Cl)c(Cl)c1
SMILES:COc1ccc(cc1)C(=O)N1CCc2c([nH]c3ccccc23)C1c1ccc(Cl)c(Cl)c1

CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 μM) with little activity at ABCG1. It has been shown to reverse the ABCG2-mediated resistance toward SN 38 and to inhibit ATPase activity.

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