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HIT212742536
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HIT212742536
  • HIT ID:HIT212742536
  • Cas No:273734-65-9
  • 常用名:N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone
    常用名:N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone
  • IUPAC:(7Z)-3-hydroxy-N-[(3S)-2-oxooxolan-3-yl]tetradec-7-enamide
    IUPAC:(7Z)-3-hydroxy-N-[(3S)-2-oxooxolan-3-yl]tetradec-7-enamide
  • InChI key:GFSFGXWHLLUVRK-UPVLWJCGSA-N
  • 分子式:C18H31NO4
  • 分子量:325.449
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):3
  • LogP:2.9157147
  • SMILES:CCCCCC\C=C/CCCC(O)CC(=O)N[C@H]1CCOC1=O
    SMILES:CCCCCC\C=C/CCCC(O)CC(=O)N[C@H]1CCOC1=O
  • N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone is a long-chain N-acyl-homoserine lactone (AHL) produced by some Gram-negative bacteria and is involved in quorum sensing. Quorum sensing enables bacteria to change gene expression based on cues from nearby bacteria and from eukaryotic hosts about nutrients, environmental conditions, or threats. Due to the benefit of quorum sensing for bacterial survival, quorum sensing molecules are potential targets for controlling bacterial infections. In mouse and human leukocyte immunoassays using LPS-stimulated macrophages, N-(3-hydroxy-7-cis tetradecenoyl)-L-homoserine lactone did not have an effect on cytokine or antibody production.
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