Name: HDAC3 Inhibitor
Rating: 5 (10 reviews)

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HIT ID:HIT212742564
Cas No:2044701-99-5
常用名:HDAC3 Inhibitor
IUPAC:(2E)-3-phenyl-N-{[4-(N'-propylhydrazinecarbonyl)phenyl]methyl}prop-2-enamide
IUPAC:(2E)-3-phenyl-N-{[4-(N'-propylhydrazinecarbonyl)phenyl]methyl}prop-2-enamide
InChI key:MHZUZIALEUTHIU-JLHYYAGUSA-N

分子式:C20H23N3O2
分子量:337.423
氢键供体数 (HBD):3
氢键受体数 (HBA):3
LogP:2.9344637
SMILES:CCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
SMILES:CCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1

HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In addition, it is selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s = 36.37, 76.64, and 151.7 nM, respectively) over chronic myeloid, acute promyelocytic, and acute lymphoblastic cells (EC50s = 2,160, >10,000, and >10,000 nM, respectively).

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