Name: SBFI AM
Rating: 5 (10 reviews)

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HIT ID:HIT212761417
Cas No:129423-53-6
常用名:SBFI AM
别名:Sodium-binding Benzofuran Isophthalate Acetoxymethyl ester
别名:Sodium-binding Benzofuran Isophthalate Acetoxymethyl ester
IUPAC:(3-{[(acetyloxy)methoxy]carbonyl}-4-(6-{13-[2-(2,4-di{[(acetyloxy)methoxy]carbonyl}phenyl)-5-methoxy-1-benzofuran-6-yl]-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl}-5-methoxy-1-benzofuran-2-yl)benzoyloxy)methyl acetate
IUPAC:(3-{[(acetyloxy)methoxy]carbonyl}-4-(6-{13-[2-(2,4-di{[(acetyloxy)methoxy]carbonyl}phenyl)-5-methoxy-1-benzofuran-6-yl]-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl}-5-methoxy-1-benzofuran-2-yl)benzoyloxy)methyl acetate
InChI key:MWUYLQGOGOLRQS-UHFFFAOYSA-N

分子式:C56H58N2O23
分子量:1127.071
氢键供体数 (HBD):0
氢键受体数 (HBA):15
LogP:6.2743654
SMILES:COc1cc2cc(oc2cc1N1CCOCCOCCN(CCOCC1)c1cc2oc(cc2cc1OC)-c1ccc(cc1C(=O)OCOC(C)=O)C(=O)OCOC(C)=O)-c1ccc(cc1C(=O)OCOC(C)=O)C(=O)OCOC(C)=O
SMILES:COc1cc2cc(oc2cc1N1CCOCCOCCN(CCOCC1)c1cc2oc(cc2cc1OC)-c1ccc(cc1C(=O)OCOC(C)=O)C(=O)OCOC(C)=O)-c1ccc(cc1C(=O)OCOC(C)=O)C(=O)OCOC(C)=O

SBFI AM is a membrane-permeant, fluorescent Na+ indicator dye. It is selective for Na+ over K+ with Kd values of 20 and 120 mM for these ions, respectively. [1]Increasing concentration of Na+ increases the ratio of excitation efficiency at 330-345 nm to that at 370-390 nm with emission collected at 450-550 nm. [1] Therefore, ratio fluorometry and imaging can be performed with the same wavelengths. SBF AM is suitable for single intracellular dye injection and is typically used for high-resolution measurements of Na+ concentration in intact tissue through two-photon confocal imaging.[2]

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