Name: Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
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HIT ID:HIT212875826
Cas No:150956-92-6
常用名:Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
常用名:Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
别名:Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
IUPAC:(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-{2-[(2S)-3-cyclohexyl-2-{[(2S)-1-(2,4-dinitrophenyl)pyrrolidin-2-yl]formamido}propanamido]acetamido}-3-(methylsulfanyl)propanamido]-3-(1H-imidazol-4-yl)propanamido]propanamido]-6-{[2-(methylamino)phenyl]formamido}hexanamide
IUPAC:(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-{2-[(2S)-3-cyclohexyl-2-{[(2S)-1-(2,4-dinitrophenyl)pyrrolidin-2-yl]formamido}propanamido]acetamido}-3-(methylsulfanyl)propanamido]-3-(1H-imidazol-4-yl)propanamido]propanamido]-6-{[2-(methylamino)phenyl]formamido}hexanamide
InChI key:FLNOECDMJTUEJM-HAHFRGJSSA-N

分子式:C49H68N14O12S
分子量:1077.23
氢键供体数 (HBD):10
氢键受体数 (HBA):15
LogP:1.2534039
SMILES:CNc1ccccc1C(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CSC)NC(=O)CNC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H]1CCCN1c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O)C(N)=O
SMILES:CNc1ccccc1C(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CSC)NC(=O)CNC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H]1CCCN1c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O)C(N)=O

Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.

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