Name: AL 6598
Rating: 5 (10 reviews)

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HIT ID:HIT212875845
Cas No:170291-06-2
常用名:AL 6598
IUPAC:propan-2-yl 2-{[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(3R)-3-cyclohexyl-3-hydroxypropyl]-3-hydroxycyclopentyl]but-2-en-1-yl]oxy}acetate
IUPAC:propan-2-yl 2-{[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(3R)-3-cyclohexyl-3-hydroxypropyl]-3-hydroxycyclopentyl]but-2-en-1-yl]oxy}acetate
InChI key:GXLUEHGRKZQLOO-QMAHXAMHSA-N

分子式:C23H39ClO5
分子量:431.01
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:3.819059
SMILES:CC(C)OC(=O)COC\C=C/C[C@H]1[C@H](Cl)C[C@@H](O)[C@@H]1CC[C@@H](O)C1CCCCC1
SMILES:CC(C)OC(=O)COC\C=C/C[C@H]1[C@H](Cl)C[C@@H](O)[C@@H]1CC[C@@H](O)C1CCCCC1

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 μM and demonstrates an EC50 value of 0.80 μM in an in vitro functional assay. Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 μg dose given twice daily.

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