Name: 2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
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HIT ID:HIT212875880
Cas No:146877-98-7
常用名:2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
常用名:2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
IUPAC:disodium hydrate [5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl phosphate
IUPAC:disodium hydrate [5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl phosphate
InChI key:HQSJCEYJAGVPJG-UHFFFAOYSA-L

分子式:C10H14N5Na2O8P
分子量:409.202
氢键供体数 (HBD):3
氢键受体数 (HBA):9
LogP:-2.0384295
SMILES:O.[Na+].[Na+].Nc1nc2n(cnc2c(=O)[nH]1)C1CC(O)C(COP([O-])([O-])=O)O1
SMILES:O.[Na+].[Na+].Nc1nc2n(cnc2c(=O)[nH]1)C1CC(O)C(COP([O-])([O-])=O)O1

2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.

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