Name: N-(α-Linolenoyl) Tyrosine
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212876066
Cas No:259143-19-6
常用名:N-(α-Linolenoyl) Tyrosine
IUPAC:(2S)-3-(4-hydroxyphenyl)-2-[(9Z,12Z,15Z)-octadeca-9,12,15-trienamido]propanoic acid
IUPAC:(2S)-3-(4-hydroxyphenyl)-2-[(9Z,12Z,15Z)-octadeca-9,12,15-trienamido]propanoic acid
InChI key:DEQLZTQITSWABQ-GMOGWPNXSA-N

分子式:C27H39NO4
分子量:441.612
氢键供体数 (HBD):3
氢键受体数 (HBA):4
LogP:6.8761973
SMILES:CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
SMILES:CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent.

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~