Name: Bis-ANS dipotassium
Rating: 5 (10 reviews)

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HIT ID:HIT212970809
Cas No:65664-81-5
常用名:Bis-ANS dipotassium
别名:bis-ANS (potassium salt), 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid
别名:bis-ANS (potassium salt), 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid
IUPAC:dipotassium 4,4'-bis(phenylamino)-[1,1'-binaphthalene]-5,5'-disulfonate
IUPAC:dipotassium 4,4'-bis(phenylamino)-[1,1'-binaphthalene]-5,5'-disulfonate
InChI key:VWLWTJHKQHRTNC-UHFFFAOYSA-L

分子式:C32H22K2N2O6S2
分子量:672.85
氢键供体数 (HBD):2
氢键受体数 (HBA):8
LogP:3.9024866
SMILES:[K+].[K+].[O-]S(=O)(=O)c1cccc2c(ccc(Nc3ccccc3)c12)-c1ccc(Nc2ccccc2)c2c(cccc12)S([O-])(=O)=O
SMILES:[K+].[K+].[O-]S(=O)(=O)c1cccc2c(ccc(Nc3ccccc3)c12)-c1ccc(Nc2ccccc2)c2c(cccc12)S([O-])(=O)=O

bis-ANS is a high-affinity non-covalent extrinsic fluorescent dye used to analyze protein conformation.[1] Its predominant interaction with proteins is through its hydrophobic phenyl and naphthyl rings.[2] bis-ANS has an excitation maxima of 390 nm.[3] It has an emission maximum of 523 nm when free in solution but undergoes a blue shift with an increase in fluorescence intensity when bound to protein; for example, when bound to intestinal fatty acid binding protein (FAPB2) it has emission maxima of 484-496 nm. bis-ANS has been used to label mechanically damaged neurons in acute brain slices.4 It also potently inhibits microtubule assembly.[5],[6]

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