Name: 11β-Prostaglandin E2
Rating: 5 (10 reviews)

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HIT ID:HIT212971543
Cas No:38310-90-6
常用名:11β-Prostaglandin E2
别名:11β-Prostaglandin E2, 11β-PGE2
IUPAC:(5Z)-7-[(1R,2R,3S)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid
IUPAC:(5Z)-7-[(1R,2R,3S)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid
InChI key:XEYBRNLFEZDVAW-YUOXZBOXSA-N

分子式:C20H32O5
分子量:352.471
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:3.22527
SMILES:CCCCC[C@H](O)\C=C\[C@H]1[C@@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
SMILES:CCCCC[C@H](O)\C=C\[C@H]1[C@@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O

11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3]

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