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  3. HIT212972261
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HIT212972261
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HIT212972261
  • HIT ID:HIT212972261
  • Cas No:1616967-52-2
  • 常用名:CAY10701
  • 别名:CAY10701
  • IUPAC:6-benzoyl-2-(pent-4-yn-1-yl)-5-phenyl-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one
    IUPAC:6-benzoyl-2-(pent-4-yn-1-yl)-5-phenyl-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one
  • InChI key:ZRRBLKLCAVULNS-UHFFFAOYSA-N
  • 分子式:C24H19N3O2
  • 分子量:381.435
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):4
  • LogP:4.713893
  • SMILES:O=C(c1[nH]c2[nH]c(CCCC#C)nc(=O)c2c1-c1ccccc1)c1ccccc1
    SMILES:O=C(c1[nH]c2[nH]c(CCCC#C)nc(=O)c2c1-c1ccccc1)c1ccccc1
  • CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively). It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells. CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body weight.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1
  • 供应商
    AA BlocksBB
    规格
    货期
    4-6周
    纯度
    -
    待询
    1

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