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  3. HIT212972372
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HIT212972372
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HIT212972372
  • HIT ID:HIT212972372
  • Cas No:889860-85-9
  • 常用名:GAT229
  • IUPAC:3-[(1S)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole
    IUPAC:3-[(1S)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole
  • InChI key:OHZDCJJHWPHZJD-IBGZPJMESA-N
  • 分子式:C22H18N2O2
  • 分子量:342.398
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):2
  • LogP:5.206734
  • SMILES:[O-][N+](=O)C[C@H](c1c([nH]c2ccccc12)-c1ccccc1)c1ccccc1
    SMILES:[O-][N+](=O)C[C@H](c1c([nH]c2ccccc12)-c1ccccc1)c1ccccc1
  • GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211. It does not activate the receptor on its own but enhances the binding and activity of CB agonists. GAT229 (1 μM) enhances the binding of the CB1 full agonist CP 55,940 to CHO cells expressing human recombinant CB1 (hCB1), as well as the activity of 2-arachidonoyl glycerol , arachidonoyl ethanolamide , and CP 55,940 in arrestin2 recruitment assays and increases ERK1/2 and PLCβ3 phosphorylation in HEK293 cells expressing hCB1. GAT229 (1 μM) enhances depolarization-induced suppression of excitation but does not inhibit excitatory postsynaptic currents (EPSCs) in murine autaptic hippocampal neurons. GAT229 (0.2%, topical) reduces intraocular pressure by 5.8 and 7.7 mm Hg after 6 and 12 hours, respectively, in a transgenic mouse model of ocular hypertension using nose, ear, eye mutation (nee) mice.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 2,780.00
    1
  • 供应商
    AA BlocksBB
    规格
    货期
    4-6周
    纯度
    -
    待询
    1

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